Drug interactions
Idelalisib + Vinblastine
Severity: Major
Idelalisib and Vinblastine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and can substantially increase exposure to vinblastine, a CYP3A substrate with a narrow therapeutic index. Toxicity such as severe myelosuppression and neurotoxicity may result.
What this interaction means in plain words
Idelalisib and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Idelalisib belongs to Oncology; Vinblastine belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition reduces vinblastine metabolic clearance.
What to do
Avoid the combination or use an alternative agent. If it cannot be avoided, reduce the vinblastine dose and monitor blood counts and neurotoxicity closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vinblastine
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Vinblastine?
MediHelp rates the interaction as major. Idelalisib and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A inhibitor and can substantially increase exposure to vinblastine, a CYP3A substrate with a narrow therapeutic index. Toxicity such as severe myelosuppression and neurotoxicity may result.
How serious is the interaction between Idelalisib and Vinblastine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination or use an alternative agent. If it cannot be avoided, reduce the vinblastine dose and monitor blood counts and neurotoxicity closely.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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