Drug interactions
Ifosfamide + Pentamidine
Severity: Moderate
Ifosfamide and Pentamidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both ifosfamide and systemic pentamidine can damage the kidney, and ifosfamide can also cause tubular toxicity and Fanconi-type syndrome. Using them together may increase the risk of acute kidney injury and electrolyte disturbances. Pentamidine can also cause dysglycaemia and QT prolongation.
What this interaction means in plain words
Ifosfamide and Pentamidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Pentamidine belongs to Anti Parasitic.
Why it happens
Additive nephrotoxicity from two agents that injure renal tubular cells.
What to do
Monitor serum creatinine, electrolytes (potassium, magnesium, phosphate) and glucose regularly, and keep patients well hydrated. Consider an alternative anti-infective if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ifosfamide and Pentamidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Ifosfamide with Pentamidine?
MediHelp rates the interaction as moderate. Ifosfamide and Pentamidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both ifosfamide and systemic pentamidine can damage the kidney, and ifosfamide can also cause tubular toxicity and Fanconi-type syndrome. Using them together may increase the risk of acute kidney injury and electrolyte disturbances. Pentamidine can also cause dysglycaemia and QT prolongation.
How serious is the interaction between Ifosfamide and Pentamidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, electrolytes (potassium, magnesium, phosphate) and glucose regularly, and keep patients well hydrated. Consider an alternative anti-infective if renal function declines.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
