Drug interactions
Ifosfamide + Tucatinib
Severity: Moderate
Ifosfamide and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a strong CYP3A inhibitor, and ifosfamide is a prodrug that depends on CYP3A4 (and CYP2B6) for both activation and for formation of neurotoxic and nephrotoxic chloroacetaldehyde. Inhibition may shift ifosfamide metabolism and change the balance between active and toxic metabolites, with uncertain clinical effect.
What this interaction means in plain words
Ifosfamide and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, altering the metabolic activation and toxic-metabolite formation of ifosfamide; the net effect is not well characterized.
What to do
Monitor for neurotoxicity, nephrotoxicity and reduced efficacy, and consider an alternative to tucatinib if feasible. Reassess renal function and mental status during each ifosfamide cycle.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Ifosfamide with Tucatinib?
MediHelp rates the interaction as moderate. Ifosfamide and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib is a strong CYP3A inhibitor, and ifosfamide is a prodrug that depends on CYP3A4 (and CYP2B6) for both activation and for formation of neurotoxic and nephrotoxic chloroacetaldehyde. Inhibition may shift ifosfamide metabolism and change the balance between active and toxic metabolites, with uncertain clinical effect.
How serious is the interaction between Ifosfamide and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neurotoxicity, nephrotoxicity and reduced efficacy, and consider an alternative to tucatinib if feasible. Reassess renal function and mental status during each ifosfamide cycle.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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