Drug interactions
Iloperidone + Indacaterol-glycopyrronium
Severity: Moderate
Iloperidone and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone prolongs the QT interval and has anticholinergic properties, so with indacaterol there is added proarrhythmic risk and with glycopyrronium additive antimuscarinic effects. This is generally manageable with monitoring.
What this interaction means in plain words
Iloperidone and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarisation and additive antimuscarinic activity.
What to do
Check ECG and electrolytes in patients with cardiac risk factors and monitor for anticholinergic effects such as constipation and urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Iloperidone and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone prolongs the QT interval and has anticholinergic properties, so with indacaterol there is added proarrhythmic risk and with glycopyrronium additive antimuscarinic effects. This is generally manageable with monitoring.
How serious is the interaction between Iloperidone and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes in patients with cardiac risk factors and monitor for anticholinergic effects such as constipation and urinary retention.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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