Drug interactions
Iloperidone + Insulin glargine
Severity: Moderate
Iloperidone and Insulin glargine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics such as iloperidone can cause hyperglycemia and metabolic changes, which may reduce control in insulin-treated diabetes. Insulin requirements may rise.
What this interaction means in plain words
Iloperidone and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Insulin glargine belongs to Endocrine.
Why it happens
Atypical antipsychotics can induce insulin resistance and weight gain, and may impair insulin secretion, via mechanisms that are not fully defined.
What to do
Monitor fasting glucose and HbA1c after starting iloperidone and adjust the insulin glargine dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Insulin glargine?
MediHelp rates the interaction as moderate. Iloperidone and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics such as iloperidone can cause hyperglycemia and metabolic changes, which may reduce control in insulin-treated diabetes. Insulin requirements may rise.
How serious is the interaction between Iloperidone and Insulin glargine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting iloperidone and adjust the insulin glargine dose as needed.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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