Drug interactions
Iloperidone + Ivabradine
Severity: Moderate
Iloperidone and Ivabradine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is not a clinically meaningful CYP3A4 inhibitor, but it prolongs QT and may add to ivabradine's bradycardic and arrhythmic effects. A pharmacokinetic interaction is unlikely.
What this interaction means in plain words
Iloperidone and Ivabradine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Ivabradine belongs to Cardiovascular.
Why it happens
Additive QT prolongation and arrhythmia risk; no established CYP3A4 inhibition.
What to do
Monitor ECG and heart rate, and correct electrolytes. Avoid in patients with baseline QT prolongation or bradycardia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ivabradine
- Atazanavir + Ivabradine Contraindicated
- Clarithromycin + Ivabradine Contraindicated
- Cobicistat + Ivabradine Contraindicated
- Conivaptan + Ivabradine Contraindicated
- Darunavir + Ivabradine Contraindicated
- Diltiazem + Ivabradine Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Ivabradine?
MediHelp rates the interaction as moderate. Iloperidone and Ivabradine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is not a clinically meaningful CYP3A4 inhibitor, but it prolongs QT and may add to ivabradine's bradycardic and arrhythmic effects. A pharmacokinetic interaction is unlikely.
How serious is the interaction between Iloperidone and Ivabradine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate, and correct electrolytes. Avoid in patients with baseline QT prolongation or bradycardia.
What other medicines interact with Ivabradine?
MediHelp also lists interactions of Ivabradine with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Ivabradine page.
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