Drug interactions
Iloperidone + Liraglutide
Severity: Moderate
Iloperidone and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics can cause hyperglycemia and weight gain, which may counteract the glycemic and weight benefits of liraglutide. Iloperidone has a relatively modest metabolic effect compared with some agents.
What this interaction means in plain words
Iloperidone and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Liraglutide belongs to Endocrine.
Why it happens
Atypical antipsychotics may induce insulin resistance and impair glucose regulation, opposing liraglutide pharmacodynamically.
What to do
Monitor fasting glucose, HbA1c and weight after starting iloperidone. Adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Iloperidone and Liraglutide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Liraglutide
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Liraglutide?
MediHelp rates the interaction as moderate. Iloperidone and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics can cause hyperglycemia and weight gain, which may counteract the glycemic and weight benefits of liraglutide. Iloperidone has a relatively modest metabolic effect compared with some agents.
How serious is the interaction between Iloperidone and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose, HbA1c and weight after starting iloperidone. Adjust antidiabetic therapy as needed.
What other medicines interact with Liraglutide?
MediHelp also lists interactions of Liraglutide with, for example, Insulin degludec-liraglutide, Insulin glargine-lixisenatide, Alogliptin-metformin. The full list is on the Liraglutide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
