Drug interactions
Iloperidone + Lurasidone
Severity: Moderate
Iloperidone and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two antipsychotics adds to sedation, orthostatic hypotension and extrapyramidal effects, with no clear benefit. Iloperidone is reported to inhibit CYP3A4 and may raise lurasidone exposure, and iloperidone also prolongs the QT interval.
What this interaction means in plain words
Iloperidone and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects, plus possible CYP3A4 inhibition by iloperidone raising lurasidone levels.
What to do
Avoid antipsychotic polypharmacy where possible. If both are needed, monitor for akathisia, sedation and hypotension, and obtain an ECG if QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Lurasidone?
MediHelp rates the interaction as moderate. Iloperidone and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two antipsychotics adds to sedation, orthostatic hypotension and extrapyramidal effects, with no clear benefit. Iloperidone is reported to inhibit CYP3A4 and may raise lurasidone exposure, and iloperidone also prolongs the QT interval.
How serious is the interaction between Iloperidone and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid antipsychotic polypharmacy where possible. If both are needed, monitor for akathisia, sedation and hypotension, and obtain an ECG if QT risk factors are present.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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