Drug interactions
Iloperidone + Meperidine
Severity: Moderate
Iloperidone and Meperidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and hypotension, and iloperidone may add to opioid-related CNS depression. Meperidine's serotonergic activity could theoretically add to serotonin toxicity risk with antipsychotics that have serotonergic action.
What this interaction means in plain words
Iloperidone and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Meperidine belongs to Musculoskeletal.
Why it happens
Additive CNS depression and orthostatic effects, plus a possible serotonergic contribution.
What to do
Monitor for sedation, orthostatic hypotension and signs of serotonin toxicity. Start with lower doses of one or both agents and adjust to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Meperidine?
MediHelp rates the interaction as moderate. Iloperidone and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and hypotension, and iloperidone may add to opioid-related CNS depression. Meperidine's serotonergic activity could theoretically add to serotonin toxicity risk with antipsychotics that have serotonergic action.
How serious is the interaction between Iloperidone and Meperidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension and signs of serotonin toxicity. Start with lower doses of one or both agents and adjust to response.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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