Drug interactions
Iloperidone + Midazolam
Severity: Minor
Iloperidone and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is mainly a CYP3A4 substrate and has no well-established inhibition of midazolam metabolism, but it may add to sedation. The combined effect is generally limited.
What this interaction means in plain words
Iloperidone and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Iloperidone belongs to Central Nervous System; Midazolam belongs to Central Nervous System.
Why it happens
Additive CNS depression; significant CYP3A4 inhibition by iloperidone is not established.
What to do
Monitor for additive sedation and orthostatic hypotension. No dose adjustment is routinely required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Midazolam?
MediHelp rates the interaction as minor. Iloperidone and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone is mainly a CYP3A4 substrate and has no well-established inhibition of midazolam metabolism, but it may add to sedation. The combined effect is generally limited.
How serious is the interaction between Iloperidone and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for additive sedation and orthostatic hypotension. No dose adjustment is routinely required.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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