Drug interactions
Iloperidone + Mirabegron
Severity: Moderate
Iloperidone and Mirabegron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is metabolized by CYP2D6 and CYP3A4, and mirabegron may increase its exposure through CYP2D6 inhibition. Higher levels could increase QT prolongation, orthostatic hypotension and sedation.
What this interaction means in plain words
Iloperidone and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Mirabegron belongs to Genitourinary.
Why it happens
Mirabegron inhibits CYP2D6, reducing iloperidone metabolism.
What to do
Monitor for orthostasis, sedation and QT effects, with ECG monitoring if other QT-prolonging drugs are present. Consider a lower iloperidone dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Mirabegron?
MediHelp rates the interaction as moderate. Iloperidone and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is metabolized by CYP2D6 and CYP3A4, and mirabegron may increase its exposure through CYP2D6 inhibition. Higher levels could increase QT prolongation, orthostatic hypotension and sedation.
How serious is the interaction between Iloperidone and Mirabegron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostasis, sedation and QT effects, with ECG monitoring if other QT-prolonging drugs are present. Consider a lower iloperidone dose.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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