Drug interactions
Iloperidone + Nabilone
Severity: Moderate
Iloperidone and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is a sedating atypical antipsychotic that can cause orthostatic hypotension and QT prolongation. Nabilone adds to drowsiness, dizziness and tachycardia, increasing the risk of falls.
What this interaction means in plain words
Iloperidone and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression and additive orthostatic hypotensive effects.
What to do
Monitor sedation and orthostatic blood pressure, especially during dose titration. Counsel patients on rising slowly and avoiding driving until response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Nabilone?
MediHelp rates the interaction as moderate. Iloperidone and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is a sedating atypical antipsychotic that can cause orthostatic hypotension and QT prolongation. Nabilone adds to drowsiness, dizziness and tachycardia, increasing the risk of falls.
How serious is the interaction between Iloperidone and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and orthostatic blood pressure, especially during dose titration. Counsel patients on rising slowly and avoiding driving until response is known.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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