Drug interactions
Iloperidone + Norethisterone
Severity: Minor
Iloperidone and Norethisterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is reported to be a weak time-dependent CYP3A inhibitor and might slightly raise norethisterone concentrations. Clinical relevance is likely small.
What this interaction means in plain words
Iloperidone and Norethisterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Iloperidone belongs to Central Nervous System; Norethisterone belongs to Endocrine.
Why it happens
Weak, time-dependent CYP3A4 inhibition by iloperidone may reduce norethisterone metabolism.
What to do
No routine adjustment is needed; watch for increased progestogenic adverse effects and reassess if they appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Iloperidone and Norethisterone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Norethisterone
- Acitretin + Norethisterone Contraindicated
- Amobarbital + Norethisterone Major
- Apalutamide + Norethisterone Major
- Belzutifan + Norethisterone Major
- Bosentan + Norethisterone Major
- Brigatinib + Norethisterone Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Norethisterone?
MediHelp rates the interaction as minor. Iloperidone and Norethisterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone is reported to be a weak time-dependent CYP3A inhibitor and might slightly raise norethisterone concentrations. Clinical relevance is likely small.
How serious is the interaction between Iloperidone and Norethisterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for increased progestogenic adverse effects and reassess if they appear.
What other medicines interact with Norethisterone?
MediHelp also lists interactions of Norethisterone with, for example, Acitretin, Amobarbital, Apalutamide. The full list is on the Norethisterone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
