Drug interactions
Iloperidone + Pentazocine
Severity: Moderate
Iloperidone and Pentazocine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation and dizziness, and the combination may increase drowsiness, orthostatic hypotension and impaired cognition. Iloperidone also prolongs the QT interval, though pentazocine is not a notable QT-prolonging drug.
What this interaction means in plain words
Iloperidone and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Pentazocine belongs to Musculoskeletal.
Why it happens
Additive CNS depressant and hypotensive effects.
What to do
Monitor for sedation and orthostatic hypotension, especially at initiation and after dose increases. Consider lowering doses and advise patients to rise slowly and avoid driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Pentazocine?
MediHelp rates the interaction as moderate. Iloperidone and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation and dizziness, and the combination may increase drowsiness, orthostatic hypotension and impaired cognition. Iloperidone also prolongs the QT interval, though pentazocine is not a notable QT-prolonging drug.
How serious is the interaction between Iloperidone and Pentazocine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic hypotension, especially at initiation and after dose increases. Consider lowering doses and advise patients to rise slowly and avoid driving.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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