Drug interactions
Iloperidone + Rimegepant
Severity: Minor
Iloperidone and Rimegepant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is not a recognized clinically significant CYP3A4 inhibitor; it is a substrate of CYP3A4 and CYP2D6. A meaningful rise in rimegepant exposure is not established.
What this interaction means in plain words
Iloperidone and Rimegepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Iloperidone belongs to Central Nervous System; Rimegepant belongs to Central Nervous System.
Why it happens
Mechanism not established; iloperidone is mainly a CYP3A4 substrate rather than an inhibitor.
What to do
No dose adjustment is needed; monitor for usual rimegepant adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rimegepant
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Rimegepant?
MediHelp rates the interaction as minor. Iloperidone and Rimegepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone is not a recognized clinically significant CYP3A4 inhibitor; it is a substrate of CYP3A4 and CYP2D6. A meaningful rise in rimegepant exposure is not established.
How serious is the interaction between Iloperidone and Rimegepant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for usual rimegepant adverse effects.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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