Drug interactions
Iloperidone + Rosiglitazone
Severity: Moderate
Iloperidone and Rosiglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics such as iloperidone may cause hyperglycemia and weight gain, which can reduce the effectiveness of rosiglitazone. Glucose control may worsen after starting the antipsychotic.
What this interaction means in plain words
Iloperidone and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Rosiglitazone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through antipsychotic-related insulin resistance and weight gain.
What to do
Check glucose and HbA1c at baseline and periodically during iloperidone therapy. Intensify antidiabetic treatment if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Rosiglitazone?
MediHelp rates the interaction as moderate. Iloperidone and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics such as iloperidone may cause hyperglycemia and weight gain, which can reduce the effectiveness of rosiglitazone. Glucose control may worsen after starting the antipsychotic.
How serious is the interaction between Iloperidone and Rosiglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check glucose and HbA1c at baseline and periodically during iloperidone therapy. Intensify antidiabetic treatment if control worsens.
What other medicines interact with Rosiglitazone?
MediHelp also lists interactions of Rosiglitazone with, for example, Insulin aspart protamine / insulin aspart, Insulin aspart-insulin aspart protamine, Insulin aspart. The full list is on the Rosiglitazone page.
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