Drug interactions
Iloperidone + Saxagliptin
Severity: Moderate
Iloperidone and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone, an atypical antipsychotic, can cause hyperglycemia and weight gain that work against antidiabetic therapy. Its weak CYP3A4 inhibition may also slightly raise saxagliptin levels.
What this interaction means in plain words
Iloperidone and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Saxagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through antipsychotic-induced metabolic effects, plus minor CYP3A4 inhibition.
What to do
Monitor fasting glucose and HbA1c and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Saxagliptin?
MediHelp rates the interaction as moderate. Iloperidone and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone, an atypical antipsychotic, can cause hyperglycemia and weight gain that work against antidiabetic therapy. Its weak CYP3A4 inhibition may also slightly raise saxagliptin levels.
How serious is the interaction between Iloperidone and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c and adjust antidiabetic therapy as needed.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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