Drug interactions
Iloperidone + Tapentadol
Severity: Moderate
Iloperidone and Tapentadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is an atypical antipsychotic that causes somnolence, orthostatic hypotension and QT prolongation. With tapentadol, sedation and hypotension may be additive.
What this interaction means in plain words
Iloperidone and Tapentadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Tapentadol belongs to Musculoskeletal.
Why it happens
Additive CNS depression and hypotension from alpha-adrenergic and histamine blockade plus opioid agonism.
What to do
Start with low doses and titrate cautiously, monitoring sedation and orthostatic blood pressure. Advise patients to rise slowly and avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Tapentadol?
MediHelp rates the interaction as moderate. Iloperidone and Tapentadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is an atypical antipsychotic that causes somnolence, orthostatic hypotension and QT prolongation. With tapentadol, sedation and hypotension may be additive.
How serious is the interaction between Iloperidone and Tapentadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and titrate cautiously, monitoring sedation and orthostatic blood pressure. Advise patients to rise slowly and avoid driving until the response is known.
What other medicines interact with Tapentadol?
MediHelp also lists interactions of Tapentadol with, for example, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid, Linezolid. The full list is on the Tapentadol page.
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