Drug interactions
Iloprost + Meperidine
Severity: Moderate
Iloprost and Meperidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloprost is a potent vasodilator that lowers blood pressure, and opioids such as meperidine can cause hypotension through histamine release and vasodilation. Together they may produce additive hypotension.
What this interaction means in plain words
Iloprost and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloprost belongs to Cardiovascular; Meperidine belongs to Musculoskeletal.
Why it happens
Additive hypotensive effects from prostacyclin-mediated vasodilation and opioid-induced vasodilation.
What to do
Monitor blood pressure and heart rate during iloprost titration. Adjust the iloprost dose if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Amiodarone + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Bupivacaine + Iloprost Moderate
- Carbidopa-entacapone-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Iloprost with Meperidine?
MediHelp rates the interaction as moderate. Iloprost and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloprost is a potent vasodilator that lowers blood pressure, and opioids such as meperidine can cause hypotension through histamine release and vasodilation. Together they may produce additive hypotension.
How serious is the interaction between Iloprost and Meperidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during iloprost titration. Adjust the iloprost dose if symptomatic hypotension develops.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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