Drug interactions
Iloprost + Nitroglycerin
Severity: Moderate
Iloprost and Nitroglycerin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are vasodilators, and combining them may produce additive blood pressure reduction. The risk is greatest with intravenous iloprost.
What this interaction means in plain words
Iloprost and Nitroglycerin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloprost belongs to Cardiovascular; Nitroglycerin belongs to Cardiovascular.
Why it happens
Additive vasodilation via prostacyclin receptor activation (iloprost) and nitric oxide/cGMP signalling (nitroglycerin).
What to do
Monitor blood pressure during iloprost infusion and consider temporarily reducing or stopping nitroglycerin. If hypotension persists, lower the iloprost dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nitroglycerin
- Avanafil + Nitroglycerin Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Nitroglycerin + Sildenafil Contraindicated
- Nitroglycerin + Tadalafil Contraindicated
- Nitroglycerin + Vardenafil Contraindicated
- Dihydroergotamine intranasal + Nitroglycerin Major
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Amiodarone + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Bupivacaine + Iloprost Moderate
- Carbidopa-entacapone-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Iloprost with Nitroglycerin?
MediHelp rates the interaction as moderate. Iloprost and Nitroglycerin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are vasodilators, and combining them may produce additive blood pressure reduction. The risk is greatest with intravenous iloprost.
How serious is the interaction between Iloprost and Nitroglycerin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during iloprost infusion and consider temporarily reducing or stopping nitroglycerin. If hypotension persists, lower the iloprost dose.
What other medicines interact with Nitroglycerin?
MediHelp also lists interactions of Nitroglycerin with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Nitroglycerin page.
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