Drug interactions
Iloprost + Tapentadol
Severity: Minor
Iloprost and Tapentadol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloprost is a vasodilator that lowers blood pressure, and opioids can add to hypotension through vasodilation and reduced sympathetic tone. The effect is usually modest and is most relevant with intravenous iloprost or in volume-depleted patients.
What this interaction means in plain words
Iloprost and Tapentadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Iloprost belongs to Cardiovascular; Tapentadol belongs to Musculoskeletal.
Why it happens
Additive hypotensive effect from prostacyclin-mediated vasodilation and opioid-related vasodilation.
What to do
Monitor blood pressure and heart rate when starting or increasing either drug. Reduce the iloprost dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Amiodarone + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Bupivacaine + Iloprost Moderate
- Carbidopa-entacapone-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Iloprost with Tapentadol?
MediHelp rates the interaction as minor. Iloprost and Tapentadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloprost is a vasodilator that lowers blood pressure, and opioids can add to hypotension through vasodilation and reduced sympathetic tone. The effect is usually modest and is most relevant with intravenous iloprost or in volume-depleted patients.
How serious is the interaction between Iloprost and Tapentadol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or increasing either drug. Reduce the iloprost dose if symptomatic hypotension occurs.
What other medicines interact with Tapentadol?
MediHelp also lists interactions of Tapentadol with, for example, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid, Linezolid. The full list is on the Tapentadol page.
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