Drug interactions
Iloprost + Tizanidine
Severity: Moderate
Iloprost and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloprost is a potent vasodilator and tizanidine lowers blood pressure through central alpha-2 agonism. Together they may cause additive hypotension, dizziness or syncope, especially with intravenous iloprost.
What this interaction means in plain words
Iloprost and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloprost belongs to Cardiovascular; Tizanidine belongs to Musculoskeletal.
Why it happens
Additive hypotensive effect from prostacyclin-mediated vasodilation and central sympatholytic action.
What to do
Monitor blood pressure when starting or titrating iloprost in a patient taking tizanidine. Reduce the dose of one agent if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Amiodarone + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Bupivacaine + Iloprost Moderate
- Carbidopa-entacapone-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Iloprost with Tizanidine?
MediHelp rates the interaction as moderate. Iloprost and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloprost is a potent vasodilator and tizanidine lowers blood pressure through central alpha-2 agonism. Together they may cause additive hypotension, dizziness or syncope, especially with intravenous iloprost.
How serious is the interaction between Iloprost and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or titrating iloprost in a patient taking tizanidine. Reduce the dose of one agent if symptomatic hypotension develops.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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