Drug interactions
Imatinib + Methamphetamine
Severity: Minor
Imatinib and Methamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP2D6 in vitro, which could reduce methamphetamine metabolism and raise its levels. Clinical evidence is limited and the effect is likely modest.
What this interaction means in plain words
Imatinib and Methamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imatinib belongs to Oncology; Methamphetamine belongs to Central Nervous System.
Why it happens
Imatinib inhibition of CYP2D6-mediated metabolism of methamphetamine.
What to do
No dose change is usually needed; monitor for exaggerated stimulant effects such as tachycardia, hypertension or agitation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Methamphetamine?
MediHelp rates the interaction as minor. Imatinib and Methamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imatinib inhibits CYP2D6 in vitro, which could reduce methamphetamine metabolism and raise its levels. Clinical evidence is limited and the effect is likely modest.
How serious is the interaction between Imatinib and Methamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for exaggerated stimulant effects such as tachycardia, hypertension or agitation.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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