Drug interactions
Imatinib + Midostaurin
Severity: Moderate
Imatinib and Midostaurin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may increase midostaurin and its active metabolite exposure. This could increase adverse reactions such as nausea, QT effects, infections and pulmonary toxicity.
What this interaction means in plain words
Imatinib and Midostaurin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Midostaurin belongs to Oncology.
Why it happens
Imatinib inhibits CYP3A4, the main metabolic route of midostaurin.
What to do
Monitor for midostaurin toxicity, especially in the first week, including ECG, nausea and respiratory symptoms. Consider alternatives where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Midostaurin
Frequently asked questions
Can I take Imatinib with Midostaurin?
MediHelp rates the interaction as moderate. Imatinib and Midostaurin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib may increase midostaurin and its active metabolite exposure. This could increase adverse reactions such as nausea, QT effects, infections and pulmonary toxicity.
How serious is the interaction between Imatinib and Midostaurin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for midostaurin toxicity, especially in the first week, including ECG, nausea and respiratory symptoms. Consider alternatives where feasible.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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