Drug interactions
Imatinib + Nevirapine
Severity: Moderate
Imatinib and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine is an inducer of CYP3A4 and may lower imatinib plasma concentrations. Reduced exposure could lessen antileukemic or antitumor response.
What this interaction means in plain words
Imatinib and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Nevirapine belongs to Anti Virals.
Why it happens
Induction of CYP3A4 by nevirapine increases the metabolic clearance of imatinib.
What to do
Monitor hematologic and molecular response to imatinib and consider an imatinib dose increase if response is inadequate, or use an alternative antiretroviral without enzyme-inducing activity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Nevirapine?
MediHelp rates the interaction as moderate. Imatinib and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine is an inducer of CYP3A4 and may lower imatinib plasma concentrations. Reduced exposure could lessen antileukemic or antitumor response.
How serious is the interaction between Imatinib and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hematologic and molecular response to imatinib and consider an imatinib dose increase if response is inadequate, or use an alternative antiretroviral without enzyme-inducing activity.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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