Drug interactions
Imatinib + Ozanimod
Severity: Moderate
Imatinib and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits BCRP and may increase exposure to the active metabolites of ozanimod. This could heighten adverse effects such as bradycardia, hepatic effects and infections.
What this interaction means in plain words
Imatinib and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Ozanimod belongs to Central Nervous System.
Why it happens
Imatinib inhibits BCRP-mediated efflux, raising ozanimod active metabolite levels.
What to do
Avoid if a reasonable alternative exists. If used, monitor heart rate, liver enzymes and signs of infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Imatinib with Ozanimod?
MediHelp rates the interaction as moderate. Imatinib and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib inhibits BCRP and may increase exposure to the active metabolites of ozanimod. This could heighten adverse effects such as bradycardia, hepatic effects and infections.
How serious is the interaction between Imatinib and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if a reasonable alternative exists. If used, monitor heart rate, liver enzymes and signs of infection.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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