Drug interactions
Imatinib + Palbociclib
Severity: Moderate
Imatinib and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP3A4 and may increase palbociclib exposure, which can worsen neutropenia and other adverse effects. The effect is expected to be moderate.
What this interaction means in plain words
Imatinib and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Palbociclib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated palbociclib metabolism by imatinib.
What to do
Monitor complete blood counts closely and reduce the palbociclib dose if neutropenia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Palbociclib
Frequently asked questions
Can I take Imatinib with Palbociclib?
MediHelp rates the interaction as moderate. Imatinib and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib inhibits CYP3A4 and may increase palbociclib exposure, which can worsen neutropenia and other adverse effects. The effect is expected to be moderate.
How serious is the interaction between Imatinib and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely and reduce the palbociclib dose if neutropenia develops.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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