Drug interactions
Imatinib + Panobinostat
Severity: Moderate
Imatinib and Panobinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may raise panobinostat exposure through CYP3A4 inhibition. Increased panobinostat levels can worsen diarrhea, thrombocytopenia and QT prolongation.
What this interaction means in plain words
Imatinib and Panobinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Panobinostat belongs to Oncology.
Why it happens
Imatinib inhibits CYP3A4, which is one of the metabolic pathways of panobinostat.
What to do
Monitor ECG, electrolytes, blood counts and GI toxicity closely. Consider reducing the panobinostat dose, as labeled for strong CYP3A inhibitors, if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Imatinib with Panobinostat?
MediHelp rates the interaction as moderate. Imatinib and Panobinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib may raise panobinostat exposure through CYP3A4 inhibition. Increased panobinostat levels can worsen diarrhea, thrombocytopenia and QT prolongation.
How serious is the interaction between Imatinib and Panobinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, electrolytes, blood counts and GI toxicity closely. Consider reducing the panobinostat dose, as labeled for strong CYP3A inhibitors, if toxicity emerges.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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