Drug interactions
Imatinib + Pretomanid
Severity: Major
Imatinib and Pretomanid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid-containing regimens are associated with hepatotoxicity, and imatinib can also cause liver injury. Combined use may increase the chance of significant liver damage.
What this interaction means in plain words
Imatinib and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Imatinib belongs to Oncology; Pretomanid belongs to Anti Bacterial.
Why it happens
Additive hepatotoxicity; no pharmacokinetic mechanism is established.
What to do
Avoid if possible. If it is necessary, monitor liver enzymes and bilirubin frequently and stop the offending drugs if hepatotoxicity develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Pretomanid
Frequently asked questions
Can I take Imatinib with Pretomanid?
MediHelp rates the interaction as major. Imatinib and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pretomanid-containing regimens are associated with hepatotoxicity, and imatinib can also cause liver injury. Combined use may increase the chance of significant liver damage.
How serious is the interaction between Imatinib and Pretomanid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If it is necessary, monitor liver enzymes and bilirubin frequently and stop the offending drugs if hepatotoxicity develops.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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