Drug interactions
Imatinib + Ranolazine
Severity: Moderate
Imatinib and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine inhibits P-glycoprotein, which may modestly raise imatinib exposure. Imatinib is also a CYP3A4 inhibitor that could increase ranolazine levels, and both can affect QT, so the combination may add to adverse effects.
What this interaction means in plain words
Imatinib and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Ranolazine belongs to Cardiovascular.
Why it happens
P-glycoprotein inhibition by ranolazine may raise imatinib levels, while imatinib CYP3A4 inhibition may raise ranolazine levels.
What to do
Monitor for imatinib adverse effects such as edema, cytopenias and liver enzyme rises, and review the ECG for QT changes. Limit ranolazine to the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Ranolazine?
MediHelp rates the interaction as moderate. Imatinib and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine inhibits P-glycoprotein, which may modestly raise imatinib exposure. Imatinib is also a CYP3A4 inhibitor that could increase ranolazine levels, and both can affect QT, so the combination may add to adverse effects.
How serious is the interaction between Imatinib and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for imatinib adverse effects such as edema, cytopenias and liver enzyme rises, and review the ECG for QT changes. Limit ranolazine to the lowest effective dose.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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