Drug interactions
Imatinib + Risperidone
Severity: Moderate
Imatinib and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP2D6 and may raise concentrations of risperidone and its active metabolite balance, increasing the risk of extrapyramidal effects and sedation. Clinical significance is likely modest.
What this interaction means in plain words
Imatinib and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Risperidone belongs to Central Nervous System.
Why it happens
Imatinib inhibits CYP2D6, reducing risperidone conversion to 9-hydroxyrisperidone.
What to do
Monitor for extrapyramidal symptoms, sedation and hypotension, and reduce the risperidone dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Imatinib with Risperidone?
MediHelp rates the interaction as moderate. Imatinib and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib inhibits CYP2D6 and may raise concentrations of risperidone and its active metabolite balance, increasing the risk of extrapyramidal effects and sedation. Clinical significance is likely modest.
How serious is the interaction between Imatinib and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and hypotension, and reduce the risperidone dose if they occur.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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