Drug interactions
Imatinib + Ruxolitinib
Severity: Moderate
Imatinib and Ruxolitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may increase ruxolitinib exposure through CYP3A4 inhibition, raising the risk of cytopenias such as thrombocytopenia and anemia. Both agents can suppress bone marrow.
What this interaction means in plain words
Imatinib and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Ruxolitinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated ruxolitinib metabolism, with additive myelosuppression.
What to do
Monitor complete blood counts frequently and adjust the ruxolitinib dose according to platelet count and labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Imatinib with Ruxolitinib?
MediHelp rates the interaction as moderate. Imatinib and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib may increase ruxolitinib exposure through CYP3A4 inhibition, raising the risk of cytopenias such as thrombocytopenia and anemia. Both agents can suppress bone marrow.
How serious is the interaction between Imatinib and Ruxolitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and adjust the ruxolitinib dose according to platelet count and labeling.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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