Drug interactions
Imatinib + Stiripentol
Severity: Moderate
Imatinib and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and induces CYP3A4 and inhibits P-glycoprotein, so imatinib concentrations may change unpredictably, usually rising. Imatinib may in turn affect stiripentol through CYP interactions. Clinical effect is variable.
What this interaction means in plain words
Imatinib and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol modulates CYP3A4 (inhibition and induction) and P-gp efflux, altering imatinib disposition.
What to do
Monitor for imatinib toxicity or reduced efficacy, using imatinib trough levels if available. Adjust the imatinib dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Imatinib with Stiripentol?
MediHelp rates the interaction as moderate. Imatinib and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and induces CYP3A4 and inhibits P-glycoprotein, so imatinib concentrations may change unpredictably, usually rising. Imatinib may in turn affect stiripentol through CYP interactions. Clinical effect is variable.
How serious is the interaction between Imatinib and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for imatinib toxicity or reduced efficacy, using imatinib trough levels if available. Adjust the imatinib dose as needed.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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