Drug interactions
Imatinib + Vadadustat
Severity: Minor
Imatinib and Vadadustat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat inhibits BCRP and may raise exposure to BCRP substrates, including imatinib to a limited extent. Imatinib adverse effects may be more frequent, though the clinical effect is probably small.
What this interaction means in plain words
Imatinib and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imatinib belongs to Oncology; Vadadustat belongs to Endocrine.
Why it happens
Vadadustat inhibits BCRP-mediated efflux of imatinib.
What to do
Monitor for imatinib adverse effects such as edema and cytopenias, and reduce the imatinib dose if toxicity occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Imatinib with Vadadustat?
MediHelp rates the interaction as minor. Imatinib and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vadadustat inhibits BCRP and may raise exposure to BCRP substrates, including imatinib to a limited extent. Imatinib adverse effects may be more frequent, though the clinical effect is probably small.
How serious is the interaction between Imatinib and Vadadustat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for imatinib adverse effects such as edema and cytopenias, and reduce the imatinib dose if toxicity occurs.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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