Drug interactions
Imatinib + Valbenazine
Severity: Moderate
Imatinib and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may increase valbenazine and active metabolite exposure by inhibiting CYP3A4. Higher exposure raises the risk of somnolence and QT prolongation.
What this interaction means in plain words
Imatinib and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imatinib belongs to Oncology; Valbenazine belongs to Central Nervous System.
Why it happens
Imatinib inhibits CYP3A4-mediated metabolism of valbenazine.
What to do
Monitor for sedation and QT effects. Consider a reduced valbenazine dose as labeled for CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Imatinib with Valbenazine?
MediHelp rates the interaction as moderate. Imatinib and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib may increase valbenazine and active metabolite exposure by inhibiting CYP3A4. Higher exposure raises the risk of somnolence and QT prolongation.
How serious is the interaction between Imatinib and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and QT effects. Consider a reduced valbenazine dose as labeled for CYP3A4 inhibitors.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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