Drug interactions
Imidapril + Insulin glargine
Severity: Moderate
Imidapril and Insulin glargine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors such as imidapril can enhance insulin sensitivity and increase the hypoglycemic effect of insulin, particularly early in therapy.
What this interaction means in plain words
Imidapril and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imidapril belongs to Cardiovascular; Insulin glargine belongs to Endocrine.
Why it happens
ACE inhibition may improve insulin sensitivity and increase peripheral glucose uptake, possibly via bradykinin.
What to do
Monitor glucose more often after starting imidapril and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Imidapril with Insulin glargine?
MediHelp rates the interaction as moderate. Imidapril and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors such as imidapril can enhance insulin sensitivity and increase the hypoglycemic effect of insulin, particularly early in therapy.
How serious is the interaction between Imidapril and Insulin glargine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose more often after starting imidapril and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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