Drug interactions
Imidapril + Nabumetone
Severity: Moderate
Imidapril and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the blood pressure lowering effect of ACE inhibitors. Together they also increase the risk of renal impairment and hyperkalemia, especially in older or volume-depleted patients.
What this interaction means in plain words
Imidapril and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imidapril belongs to Cardiovascular; Nabumetone belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory prostaglandins opposes ACE inhibitor effects and reduces glomerular perfusion.
What to do
Monitor blood pressure, serum creatinine and potassium after starting the NSAID and keep patients hydrated. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Imidapril with Nabumetone?
MediHelp rates the interaction as moderate. Imidapril and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the blood pressure lowering effect of ACE inhibitors. Together they also increase the risk of renal impairment and hyperkalemia, especially in older or volume-depleted patients.
How serious is the interaction between Imidapril and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting the NSAID and keep patients hydrated. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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