Drug interactions
Imipramine + Liothyronine
Severity: Moderate
Imipramine and Liothyronine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormone may increase sensitivity to catecholamines and enhance the effects of tricyclics, and tricyclics may do likewise to thyroid hormone. This can lead to tachycardia, arrhythmias and CNS stimulation, although the combination is also sometimes used purposefully to augment antidepressants.
What this interaction means in plain words
Imipramine and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Liothyronine belongs to Endocrine.
Why it happens
Increased adrenergic receptor sensitivity and pharmacodynamic synergy.
What to do
Monitor heart rate, ECG and mental state, especially in older patients or those with cardiac disease. Adjust doses based on thyroid function and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
Frequently asked questions
Can I take Imipramine with Liothyronine?
MediHelp rates the interaction as moderate. Imipramine and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormone may increase sensitivity to catecholamines and enhance the effects of tricyclics, and tricyclics may do likewise to thyroid hormone. This can lead to tachycardia, arrhythmias and CNS stimulation, although the combination is also sometimes used purposefully to augment antidepressants.
How serious is the interaction between Imipramine and Liothyronine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and mental state, especially in older patients or those with cardiac disease. Adjust doses based on thyroid function and clinical response.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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