Drug interactions
Imipramine + Lisdexamfetamine
Severity: Major
Imipramine and Lisdexamfetamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate amphetamine effects by raising amphetamine levels via CYP2D6 inhibition and by increasing noradrenergic activity. This may cause hypertension, tachycardia, arrhythmias, agitation and possible serotonergic toxicity.
What this interaction means in plain words
Imipramine and Lisdexamfetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Imipramine belongs to Central Nervous System; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Additive noradrenergic and serotonergic activity, with possible tricyclic inhibition of amphetamine metabolism.
What to do
Avoid if possible; if both are needed, begin with low doses and monitor blood pressure, heart rate and mental status, adjusting doses accordingly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Lisdexamfetamine?
MediHelp rates the interaction as major. Imipramine and Lisdexamfetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclic antidepressants can potentiate amphetamine effects by raising amphetamine levels via CYP2D6 inhibition and by increasing noradrenergic activity. This may cause hypertension, tachycardia, arrhythmias, agitation and possible serotonergic toxicity.
How serious is the interaction between Imipramine and Lisdexamfetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if both are needed, begin with low doses and monitor blood pressure, heart rate and mental status, adjusting doses accordingly.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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