Drug interactions
Imipramine + Metoclopramide
Severity: Moderate
Imipramine and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both can cause extrapyramidal and central adverse effects, and tricyclics such as imipramine may be linked with increased risk of serotonin-related toxicity with metoclopramide. Sedation and anticholinergic effects may also reduce the prokinetic effect.
What this interaction means in plain words
Imipramine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive dopaminergic/CNS effects and possible serotonergic toxicity; anticholinergic opposition of prokinetic action.
What to do
Monitor for tremor, rigidity, agitation, hyperthermia and sedation. Use the lowest doses and shortest metoclopramide course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Metoclopramide?
MediHelp rates the interaction as moderate. Imipramine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both can cause extrapyramidal and central adverse effects, and tricyclics such as imipramine may be linked with increased risk of serotonin-related toxicity with metoclopramide. Sedation and anticholinergic effects may also reduce the prokinetic effect.
How serious is the interaction between Imipramine and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tremor, rigidity, agitation, hyperthermia and sedation. Use the lowest doses and shortest metoclopramide course.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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