Drug interactions
Imipramine + Propofol
Severity: Moderate
Imipramine and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine may add to the sedative and hypotensive effects of propofol, and tricyclics can increase the risk of arrhythmia and blood pressure lability during anesthesia. The interaction is usually manageable with titration.
What this interaction means in plain words
Imipramine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depression and cardiovascular effects.
What to do
Titrate propofol to effect with continuous ECG and blood pressure monitoring. Inform the anesthesia team of tricyclic use before the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Propofol
Frequently asked questions
Can I take Imipramine with Propofol?
MediHelp rates the interaction as moderate. Imipramine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine may add to the sedative and hypotensive effects of propofol, and tricyclics can increase the risk of arrhythmia and blood pressure lability during anesthesia. The interaction is usually manageable with titration.
How serious is the interaction between Imipramine and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect with continuous ECG and blood pressure monitoring. Inform the anesthesia team of tricyclic use before the procedure.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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