Drug interactions
Indacaterol + Maprotiline
Severity: Major
Indacaterol and Maprotiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline, a tetracyclic antidepressant, can prolong QT and has adrenergic effects, and indacaterol may potentiate cardiovascular adverse effects. Arrhythmia risk may increase.
What this interaction means in plain words
Indacaterol and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol belongs to Respiratory; Maprotiline belongs to Central Nervous System.
Why it happens
Additive QT prolongation and sympathomimetic cardiovascular stimulation.
What to do
Monitor ECG, heart rate and electrolytes, and consider an alternative antidepressant in patients with arrhythmia risk.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Indacaterol with Maprotiline?
MediHelp rates the interaction as major. Indacaterol and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Maprotiline, a tetracyclic antidepressant, can prolong QT and has adrenergic effects, and indacaterol may potentiate cardiovascular adverse effects. Arrhythmia risk may increase.
How serious is the interaction between Indacaterol and Maprotiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, heart rate and electrolytes, and consider an alternative antidepressant in patients with arrhythmia risk.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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