Drug interactions
Indacaterol + Propafenone
Severity: Moderate
Indacaterol and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone is a class IC antiarrhythmic that slows conduction and can prolong QRS and QT intervals. Indacaterol may add proarrhythmic risk through sympathetic stimulation and potassium lowering.
What this interaction means in plain words
Indacaterol and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol belongs to Respiratory; Propafenone belongs to Cardiovascular.
Why it happens
Additive effects on cardiac conduction and repolarization, with beta-2 agonist-related hypokalemia.
What to do
Monitor ECG and heart rhythm, and correct electrolyte abnormalities. Report palpitations or syncope promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Indacaterol and Propafenone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Indacaterol
Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Indacaterol with Propafenone?
MediHelp rates the interaction as moderate. Indacaterol and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propafenone is a class IC antiarrhythmic that slows conduction and can prolong QRS and QT intervals. Indacaterol may add proarrhythmic risk through sympathetic stimulation and potassium lowering.
How serious is the interaction between Indacaterol and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rhythm, and correct electrolyte abnormalities. Report palpitations or syncope promptly.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
