Drug interactions
Indacaterol + Quinidine
Severity: Major
Indacaterol and Quinidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine is a well-known QT-prolonging antiarrhythmic with a clear torsades risk. Indacaterol can aggravate this through hypokalemia and sympathetic stimulation.
What this interaction means in plain words
Indacaterol and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol belongs to Respiratory; Quinidine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation, with beta-2 agonist hypokalemia increasing proarrhythmic risk.
What to do
Monitor ECG and QTc closely and correct potassium and magnesium. Consider alternatives if QTc lengthens significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Indacaterol with Quinidine?
MediHelp rates the interaction as major. Indacaterol and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quinidine is a well-known QT-prolonging antiarrhythmic with a clear torsades risk. Indacaterol can aggravate this through hypokalemia and sympathetic stimulation.
How serious is the interaction between Indacaterol and Quinidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and QTc closely and correct potassium and magnesium. Consider alternatives if QTc lengthens significantly.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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