Drug interactions
Indacaterol + Quizartinib
Severity: Major
Indacaterol and Quizartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quizartinib causes dose-related QT prolongation and carries a boxed warning for torsades de pointes. Indacaterol may add modest QTc effects and cause hypokalemia, increasing the arrhythmia risk.
What this interaction means in plain words
Indacaterol and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol belongs to Respiratory; Quizartinib belongs to Oncology.
Why it happens
Additive QTc prolongation, with beta-2 agonist-related hypokalemia further increasing risk.
What to do
Monitor ECG more frequently and keep potassium and magnesium within normal range. Consider an alternative bronchodilator if QTc rises significantly, or reduce or interrupt quizartinib per its labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amitriptyline + Quizartinib Major
- Amobarbital + Quizartinib Major
Frequently asked questions
Can I take Indacaterol with Quizartinib?
MediHelp rates the interaction as major. Indacaterol and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quizartinib causes dose-related QT prolongation and carries a boxed warning for torsades de pointes. Indacaterol may add modest QTc effects and cause hypokalemia, increasing the arrhythmia risk.
How serious is the interaction between Indacaterol and Quizartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG more frequently and keep potassium and magnesium within normal range. Consider an alternative bronchodilator if QTc rises significantly, or reduce or interrupt quizartinib per its labeling.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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