Drug interactions
Indacaterol + Ritonavir
Severity: Moderate
Indacaterol and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir inhibits CYP3A4 and P-glycoprotein and can raise systemic indacaterol exposure, which may intensify beta-agonist effects such as tachycardia, tremor and hypokalemia. Both agents can also affect QT interval, so arrhythmia risk may be somewhat higher.
What this interaction means in plain words
Indacaterol and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol belongs to Respiratory; Ritonavir belongs to Anti Virals.
Why it happens
Ritonavir inhibits CYP3A4 and P-gp mediated clearance of indacaterol, with possible additive QT effects.
What to do
Use the usual indacaterol dose and monitor heart rate, palpitations, serum potassium and ECG in patients with cardiac risk factors. Avoid adding further QT-prolonging drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Indacaterol with Ritonavir?
MediHelp rates the interaction as moderate. Indacaterol and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir inhibits CYP3A4 and P-glycoprotein and can raise systemic indacaterol exposure, which may intensify beta-agonist effects such as tachycardia, tremor and hypokalemia. Both agents can also affect QT interval, so arrhythmia risk may be somewhat higher.
How serious is the interaction between Indacaterol and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the usual indacaterol dose and monitor heart rate, palpitations, serum potassium and ECG in patients with cardiac risk factors. Avoid adding further QT-prolonging drugs where possible.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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