Drug interactions
Indacaterol + Thioridazine
Severity: Major
Indacaterol and Thioridazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine strongly prolongs the QT interval and is associated with torsades de pointes. Indacaterol can worsen this risk through hypokalemia and sympathetic stimulation.
What this interaction means in plain words
Indacaterol and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol belongs to Respiratory; Thioridazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation with beta-2 agonist-induced hypokalemia.
What to do
Avoid if possible and choose an alternative. If used together, monitor ECG and electrolytes closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Indacaterol with Thioridazine?
MediHelp rates the interaction as major. Indacaterol and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Thioridazine strongly prolongs the QT interval and is associated with torsades de pointes. Indacaterol can worsen this risk through hypokalemia and sympathetic stimulation.
How serious is the interaction between Indacaterol and Thioridazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and choose an alternative. If used together, monitor ECG and electrolytes closely.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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