Drug interactions
Indacaterol + Tranylcypromine
Severity: Major
Indacaterol and Tranylcypromine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can potentiate the cardiovascular effects of beta-2 agonists, leading to tachycardia, hypertensive reactions and arrhythmias. Labeling advises extreme caution with indacaterol in patients on MAO inhibitors.
What this interaction means in plain words
Indacaterol and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol belongs to Respiratory; Tranylcypromine belongs to Central Nervous System.
Why it happens
MAO inhibition increases catecholamine availability and potentiates the sympathomimetic effects of indacaterol.
What to do
Avoid if possible, or use with close monitoring of blood pressure, heart rate and ECG. Consider alternative bronchodilator therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Indacaterol with Tranylcypromine?
MediHelp rates the interaction as major. Indacaterol and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. MAO inhibitors can potentiate the cardiovascular effects of beta-2 agonists, leading to tachycardia, hypertensive reactions and arrhythmias. Labeling advises extreme caution with indacaterol in patients on MAO inhibitors.
How serious is the interaction between Indacaterol and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, or use with close monitoring of blood pressure, heart rate and ECG. Consider alternative bronchodilator therapy.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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