Drug interactions
Indacaterol + Vardenafil
Severity: Moderate
Indacaterol and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vardenafil can cause modest QT prolongation, and indacaterol may add to arrhythmic risk through beta2-adrenergic cardiac stimulation and potassium lowering. The combination may raise the chance of ventricular arrhythmias in susceptible patients. The clinical significance is generally small at usual doses.
What this interaction means in plain words
Indacaterol and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol belongs to Respiratory; Vardenafil belongs to Genitourinary.
Why it happens
Additive effects on cardiac repolarization and heart rate via beta2-agonism and mild vardenafil-related QT prolongation.
What to do
Avoid in patients with congenital long QT syndrome or other QT-prolonging therapy. Otherwise monitor for palpitations and consider an ECG in those with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Frequently asked questions
Can I take Indacaterol with Vardenafil?
MediHelp rates the interaction as moderate. Indacaterol and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vardenafil can cause modest QT prolongation, and indacaterol may add to arrhythmic risk through beta2-adrenergic cardiac stimulation and potassium lowering. The combination may raise the chance of ventricular arrhythmias in susceptible patients. The clinical significance is generally small at usual doses.
How serious is the interaction between Indacaterol and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with congenital long QT syndrome or other QT-prolonging therapy. Otherwise monitor for palpitations and consider an ECG in those with cardiac risk factors.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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