Drug interactions
Indacaterol + Verapamil
Severity: Minor
Indacaterol and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits P-glycoprotein and CYP3A4, both involved in indacaterol clearance, and raises indacaterol systemic exposure. The increase is modest and was not considered clinically important at the recommended inhaled dose. Higher exposure could in principle increase beta-agonist effects such as tachycardia and tremor.
What this interaction means in plain words
Indacaterol and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indacaterol belongs to Respiratory; Verapamil belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein and CYP3A4 by verapamil reduces systemic clearance of indacaterol.
What to do
No dose adjustment is needed at the recommended indacaterol dose. Monitor for tachycardia, tremor and hypokalemia if symptoms appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indacaterol
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Indacaterol with Verapamil?
MediHelp rates the interaction as minor. Indacaterol and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil inhibits P-glycoprotein and CYP3A4, both involved in indacaterol clearance, and raises indacaterol systemic exposure. The increase is modest and was not considered clinically important at the recommended inhaled dose. Higher exposure could in principle increase beta-agonist effects such as tachycardia and tremor.
How serious is the interaction between Indacaterol and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed at the recommended indacaterol dose. Monitor for tachycardia, tremor and hypokalemia if symptoms appear.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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